The Bordetella genus is formed by 8 species, of which only the following are human pathogens: B. pertussis, B. parapertussis and B. holmesii. There is a fourth, B. bronquiseptica, which normally is limited to animals, although some cases have been reported in immunocompromised patients.

Both B. pertussis and B. parapertussis are highly efficient pathogens that establish respiratory infection and remain located in the upper respiratory tract. The disease caused by B. pertussis and B. parapertussis is known as whooping cough (pertussis). It is a major risk today, as there are 50 million cases a year with 300,000 deaths (most of them in infants and neonates). Therefore, a reliable diagnosis is required to start appropriate treatment and contact prophylaxis.

The diagnosis of Bordetellas based on cultures or serological techniques presents special requirements, these are sometimes very expensive over time or do not present good sensitivity data. For this reason, molecular techniques detecting insertion sequences (IS) present in multiple copies per genome, can be an interesting alternative for the sensitive detection of these pathogens.

The Real Respiratory Bacterial Panel 2 (B. pertussis, B. parapertussis, B. holmesii) allows the differential detection of infections caused by B. pertussis, B. parapertussis y B. holmesii in samples from the respiratory tract (nasopharyngeal swabs, nasopharyngeal lavages, nasopharyngeal aspirates, etc.) in a simple, inexpensive and reliable way.

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